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J Enzyme Inhib Med Chem ; 36(1): 1258-1267, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1263614

ABSTRACT

COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction. Therefore, targeting mitochondrion will represent a more rational treatment of COVID-19. The current work outlines how COVID-19's signs and symptoms are related to the mitochondrion. Proper understanding of the underlying causes might enhance the opportunity to treat COVID-19.


Subject(s)
COVID-19 Drug Treatment , COVID-19/pathology , Mitochondria/drug effects , Mitochondria/pathology , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , COVID-19/metabolism , Humans , Mitochondria/metabolism , SARS-CoV-2/drug effects , SARS-CoV-2/pathogenicity
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